Publications

Novel pharmacological actions of natural antagonists derived from K. brevis (red tide)

Novel pharmacological actions of natural antagonists derived from K. brevis (red tide)

Brevenal and B-naphthoyl brevetoxin (B-Nap) are two antagonists derived from Florida red tide organisms. We previously reported that aerosol treatment with nMolar concentrations of these agents (20 breaths of 1ng/mL): a) improves mucociliary clearance (MCC) and b) prevents and reverses human neutrophil elastase (HNE)-induced slowing of MCC, responses not seen with inhaled glucocorticosteroids (Am J Respir Crit Care Med. 177: A457, A863, 2008). These actions suggested that brevenal and B-Nap are potential drug candidates for the treatment of diseases associated with MCC dysfunction.

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Harmful Algae. 2013 June.

Harmful Algae. 2013 June.

Brevetoxins are a family of ladder-frame polyether toxins produced by the marine dinoflagellate
Karenia brevis. During blooms of K. brevis, inhalation of brevetoxins aerosolized by wind and
wave action can lead to asthma-like symptoms in persons at the beach. Consumption of either
shellfish or finfish contaminated by K. brevis blooms can lead to the development of neurotoxic
shellfish poisoning.

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Effects of Voltage Sensitive Sodium Channel (VSSC) Blockers on 
Normal and Impaired Whole Lung Mucociliary Clearance  in Sheep

Effects of Voltage Sensitive Sodium Channel (VSSC) Blockers on Normal and Impaired Whole Lung Mucociliary Clearance in Sheep

Impaired mucociliary clearance (MCC) is a common pathophysiological characteristic of asthma, COPD and cystic fibrosis (CF). One approach used to identify potential therapies to combat these disease-related reductions in MCC is to demonstrate that an agent can improve MCC in normal airways.

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Brevenal Is a Natural Inhibitor of Brevetoxin Action in Sodium Channel Receptor Binding Assays

Brevenal Is a Natural Inhibitor of Brevetoxin Action in Sodium Channel Receptor Binding Assays

Florida red tides occur in the Gulf of Mexico and result from blooms of the marine dinoflagellate Karenia brevis (Daugbjerg et al., 2000; Steidinger and Ingle, 1972). K. brevis produces highly potent polyether toxins known as brevetoxins that activate voltage-sensitive sodium channels.

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A Kinder Side of Red Tides?

A Kinder Side of Red Tides?

Investigators conducting a decade-long study into how Florida's "red tide" algal blooms affect human health have discovered several compounds that counteract the toxins produced by the red tide dinoflagellate, Karenia brevis. In an intriguing twist, they are now developing one of these compounds, brevenal, as a potential treatment for cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). In cellular and animal models brevenal appears far more potent than existing drugs for CF and COPD and exhibits the unique quality of both suppressing inflammation and boosting mucociliary clearance.

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Novel pharmacological actions of natural antagonists derived from K. brevis (red tide)

Novel pharmacological actions of natural antagonists derived from K. brevis (red tide)

Brevenal and B-naphthoyl brevetoxin (B-Nap) are two antagonists derived from Florida red tide organisms. We previously reported that aerosol treatment with nMolar concentrations of these agents (20 breaths of 1ng/mL): a) improves mucociliary clearance (MCC) and b) prevents and reverses human neutrophil elastase (HNE)-induced slowing of MCC, responses not seen with inhaled glucocorticosteroids (Am J Respir Crit Care Med. 177: A457, A863, 2008)

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